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Description
NAP-2/CXCL7 Protein, HumanProduct Specification Species Human Synonyms PPBP, B TG1, Beta TG, CTAP III, CTAP3, CTAPIII, CXCL 7, LA PF4, LDGF, MDGF, NAP2, PBP, SCYB7, TC1, TC2, TGB, TGB1, THBGB, THBGB1, pro platelet basic protein Accession P02775 Amino Acid Sequence Ala59 Asp128 Expression System E. coli Molecular Weight 9kDa (Reducing) Purity >95% by SDS PAGE Endotoxin <0. 1EU g Conjugation Unconjugated Tag No Tag Physical Appearance Lyophilized Powder Storage Buffer 20mM Tris,
Product Specification
| Species | Human |
| Synonyms | PPBP, B-TG1, Beta-TG, CTAP-III, CTAP3, CTAPIII, CXCL-7, LA-PF4, LDGF, MDGF, NAP2, PBP, SCYB7, TC1, TC2, TGB, TGB1, THBGB, THBGB1, pro-platelet basic protein |
| Accession | P02775 |
| Amino Acid Sequence | Ala59-Asp128 |
| Expression System | E.coli |
| Molecular Weight | 9kDa (Reducing) |
| Purity | >95% by SDS-PAGE |
| Endotoxin | <0.1EU/μg |
| Conjugation | Unconjugated |
| Tag | No Tag |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | 20mM Tris, 300mM NaCl, pH8.0 |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| Stability & Storage | · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. · 3 months, -20 to -80℃ under sterile conditions after reconstitution. · 1 week, 2 to 8℃ under sterile conditions after reconstitution. · Please avoid repeated freeze-thaw cycles. |
| Reference |
Wang YH, Shen CY, Lin SC, Kuo WH, Kuo YT, Hsu
YL, Wang WC, Lin KT, Wang LH. Monocytes secrete CXCL7 to promote breast cancer
progression. Cell Death Dis. 2021 Nov 17;12(12):1090. doi:
10.1038/s41419-021-04231-4. PMID: 34789744; PMCID: PMC8599470.
|
Background
Neutrophil
Activating Peptide 2 (NAP-2), also known as CXCL7, is a platelet-derived
growth factor that belongs to the CXC chemokine family. This growth factor is
a potent chemoattractant and activator of neutrophils. Recently, it has been
shown that CXCL7 is secreted by tumor infiltrating monocytes, to stimulate
cancer cell migration, invasion, and metastasis, contributing to the
promotion of breast cancer progression. It also stimulates the formation and
secretion of plasminogen activator by synovial cells. The protein also is an
antimicrobial protein with bactericidal and antifungal activity.
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4.8 ★★★★★
Based on 1484 reviews
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Product Reviews
★★★★★ 4
Fun Seeing Where it All Begins for the Fantastic Amateur Detecting Duo
Format: Audiobook
I started with book three in this series, progressed forward, and finally took the opportunity to go back and get the first book in the series. The whimsical, cozy mystery paired with historical Edwardian setting was light and whimsical.
Actually, when I started listening, I realized that the first book introduced Lady Hardcastle and her ladies' maid, Florence Armstrong along with their new home and the other regular characters, in such a way that it didn't feel like the first book so much as the first of the stories that had been recorded. There are hints of their unusual, dangerous work abroad and no big explanation why the pair happened to be set upon 'a quiet life in the country' or why Lady Hardcastle and Florence have a relationship that is nearly family rather than an employer and servant from separate classes. The author trickles out the details and the reader/listener must catch them and piece them together as they go. Because I had experienced later books, those pieces stuck out easily to me. The meeting with Inspector Sunderland and the local villagers and neighborhood was fun.
There are two murder mysteries that have interesting crossover people and facts. One seems to involve a dead man from the village cricket team whose death was meant to appear like a suicide and then later, the death of a rag-time band trumpeteer that played at the engagement party of the local squire's daughter. A theft is tossed in for good measure.
I figured out one of the murders and part of the theft and the second murder, but the ultimate solution took me by surprise. Loved seeing the intrepid Flo able to get in some of her martial arts ability and spend time trailing along as they teased out the solution along side Inspector Sunderland.
Elizabeth Knowelden is an absolute gem of a narrator and the voice of this series for me. She laid out the Edwardian country village world, the variety of genders and accents, and kept the pace and tone for this series just right.
All in all, I thought this first entry was as fabulous as the later books and do not hesitate to put it out there as a good bet for historical cozy mystery lovers.
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Reviewed in the United States on March 22, 2019
★★★★★ 5
Must read!!!!
Format: Paperback, Format: Paperback
Surprise plot intertwined with story of loss, grief, family and sibling relationships. The book starts off normally and twists and turns. Could not put book down. Great writing and plot development. Can’t wait to read more by this author.
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Reviewed in the United States on May 25, 2026
★★★★★ 4
A story about what's left behind after death, both emotionally & spiritually - oh, and evil puppets
Format: Kindle
It takes a bit for Grady Hendrix's How to Sell a Haunted House to get to the "haunted" part of that title, but that's okay, really; what Hendrix is interested in here, as much as anything, is haunting in terms of the literal things left behind by death - the traumas that are left for those who survive, the guilt, the shame, the baggage, and all of the other things left behind by those who went before us. And, in the case of Louise and Mark Joyner, puppets. Lots and lots and lots of puppets. Oh, and one of them might be alive and malevolent, turning all of that metaphorical trauma into a very real presence (and, without getting into spoiler territory, all without losing that symbolic weight) - and one that allows Hendrix to bring real horror into the story of an estranged pair of siblings forced back into contact in the weight of their parents' death, and the reckoning that they have to go through as they deal with painful memories and a nightmare puppet. The end result can feel a little cluttered at times (although, by the end, it turns out to be a lot more interconnected and structured than you might realize along the way), and it doesn't help that it features some very fraught family interactions that cross from "painful" to "infuriating" very quickly. But as ever with Hendrix, there's more heart and emotion here than you might expect, and while it's all handled in his usual slightly off-kilter and unique sensibility, it still knows how to deliver the goods both on a horror front and a character one. I'd put it among the weakest of Hendrix's efforts overall, but there's a caveat here, and it's that I don't think anything he's read has ever been anything less than entertaining and solid overall, so even a weaker entry? Still a good time and a good read.
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Reviewed in the United States on October 8, 2023
★★★★★ 3
Exactly as advertised
Format: Hardcover
REVIEW: How to Sell a Haunted House by Grady Hendrix
If you've enjoyed Grady Hendrix's previous books, you're probably going to like this one. It is Grady in typical form - witty, entertaining, slightly spooky, grounded characters who contrast over-the-top characters, and drenched in South Carolina charm. Now, if you're not the biggest Grady fan, I doubt this will be the book that converts you for the same reasons mentioned above.
I tend to fall in the middle. I enjoy his storytelling abilities and scenarios enough to keep reading his books, but there's nothing horrific about them, nor any lingering effects. To me, they are entry-level horror, and that's perfectly fine. There's a huge market for that as his success reflects. This book doesn't try to be anything other than what it is, and I respect that.
The story begins with Louise getting the news that her parents were killed in a car crash. She travels from California back to her hometown of Charleston, South Carolina where she reluctantly reunites with her cousins, aunt, and her brother, Mark. Louise and Mark resent one another, so they butt heads at every decision that needs to be made in light of the tragedy. Louise sees herself as the reasonable one and looks down on her brother as an embarrassment and a failure. While trying to come to terms with selling the house, the siblings soon realize that there's another presence in there with them, and it has something to do with their mom's homemade puppet collection.
Overall, this book was enjoyable. There was nothing groundbreaking about it, and I got exactly what I paid for. Check it out if you're into spooky stories about complicated families and southern settings.
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Reviewed in the United States on January 27, 2023
★★★★★ 5
Disturbing and Hilarious
Format: Paperback
4.5/5
I LOVED this book! The characters are frustrating, complicated, and loveable and hateable at the same time. It somehow walks the fine line of being hilarious and genuinely disturbing. For me, the entire puppet thing was hard to take seriously at first because, I mean, how much damage can a PUPPET do? But wow it soon took a dark turn and was truly scary!
If you find Mark to be really aggravating at first, just hold on because it gets better. The character arcs in this book are awesome.
Overall, I found this novel to have really unique events that I didn't see coming at all and was excited the whole time I was reading.
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Reviewed in the United States on January 13, 2026